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Endocrine Abstracts

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ea0011p519 | Endocrine tumours and neoplasia | ECE2006

Radiotherapy and o,p’-DDD induce an inhibition of growth and interfere in the cell cycle in H295-R adrenocortical cell line

Stigliano AS , Cerquetti LC , Bucci BB , Carlini PC , Amendola DA , Misiti SM , Miceli RM , de Paula UDP , Brunetti EB , Toscano VT

Background: Mitotane,(o,p’-DDD)is a compound with potent adrenotoxic effect and is able to block cortisol synthesis by inhibiting 11β-hydroxylation and cholesterol chain cleavage. For these reasons, mitotane was widely used in the treatment of adrenocortical cancer. Nevertheless the biological mechanism induced by these treatments in this cancer cells remain unknown.Aim: To study whether the o,p’-DDD could increase the susceptibility to th...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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